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RRG1-16004

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​​Exploring New Treatment of Spinal Cord Injury by Synergising Regenerative Medicine and Rehabilitation​​
Research Programmes Precision Rehabilitation​
Clinical PI:​​  Dr Tow Peh Er, Adela May
Senior Consultant, Department of Rehabilitation Medicine, Tan Tock Seng Hospital​
​Technical PI:  ​A/Prof Chew Sing Yian​
Associate Professor, Lee Kong Chian School of Medicine 
Associate Professor, School of Chemical & Biomedical Engineering, Nanyang Technological University

Spinal cord injuries (SCI) result in devastating outcomes of paralysis and functional impairment and are the major causes of morbidity and mortality, particularly in young adults and children. Here, we propose a novel treatment for SCI by synergistic approaches of regenerative medicine and neural rehabilitation. Specifically, we will implant nanofiber scaffolds that are endowed with growth factors to enhance nerve regeneration. We hypothesize that enhancing tissue regeneration and physiotherapy after SCI are critical to nerve regeneration and function recovery, and may be achieved through regenerative approaches using biological factors and nanofiber scaffolds, coupled with neural rehabilitation. We propose to pursue the following: 
1) Establish a robust platform to provide reproducible and effective delivery of neurotrophic factors for axon regeneration. 
2) Establish a robust combinatorial regenerative and rehabilitative approach to enhance axon regeneration and function recovery in SCI treatment. Results from this study will help advance SCI treatment methods. Our long-term goal is to compliment or even change the current clinical SCI treatment from rehabilitation to regeneration.​





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